Isotope studies on the pathways of glucose-6-phosphate metabolism in the Novikoff hepatoma.
نویسندگان
چکیده
منابع مشابه
Glucose-6-phosphatase activity in regenerating, embryonic, and newborn rat liver.
Studies on carbohydrate metabolism have dem onstrated important differences between normal liver and hepatoma (3, 9,17). Since it seemed that the deviation of the carbohydrate metabolism of the hepatoma from that of the normal liver starts at the utilization of the G-6-P1 ester, a systematic study of G-6-P utilization was undertaken in this laboratory. One of the most important pathways of G-6-...
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Previous studies on the carbohydrate metabolism of neoplastic liver have established definite qualitative and quant i ta t ive alterations in the glucose-6-phosphate (G-6-P) utilization of this tumor. The G-6-P metabolism was examined in homogenates and supernatantfluid of Novikoff hepatoma and control tissues by studying the behavior of enzymes directly involved in the utilization of this hexo...
متن کاملFructose-1,6-diphosphatases and lactic dehydrogenase activity in hepatoma and in control human and animal tissues.
Previous studies on the carbohydrate metabolism of neoplastic liver have established definite qualitative and quant i ta t ive alterations in the glucose-6-phosphate (G-6-P) utilization of this tumor. The G-6-P metabolism was examined in homogenates and supernatantfluid of Novikoff hepatoma and control tissues by studying the behavior of enzymes directly involved in the utilization of this hexo...
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A systematic study of the carbohydrate-metabolizing enzyme systems of the Morris hepatoma 51~3 was carried out, and results were interpreted in the light of normal liver data and in comparison with previously established values of Novikoff hepatoma. The cellularity of the Morris tumor was in the same range, whereas the nitrogen content of the average cell was significantly decreased, as compare...
متن کاملGlycogen metabolism in Novikoff ascites-hepatoma cells.
A study of the enzymes of the glycogen pathway in Novikoff ascites hepatoma shows that glycogen synthetase has the lowest activity and that the tumour contains no high-K(m) soluble glucokinase. However, incubation of tumour cells with metabolizable sugars in vitro, or intraperitoneal administration of glucose into the tumour-bearing rat, results in glycogen accumulation by the tumour cells. Gly...
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ورودعنوان ژورنال:
- Cancer research
دوره 18 8 Part 1 شماره
صفحات -
تاریخ انتشار 1958